Previously studied models of congenital pericyte deficiency rely on either reduced bioavailability of endothelial platelet-derived growth factor-B (PDGF-BB; Armulik et al., 2010; Keller et al., 2013) or globally inherited platelet-derived growth factor receptor-β (PDGFRβ) deficiency in pericytes (Bell et al., 2010; Daneman et al., 2010; Nikolakopoulou et al., 2017). This evidence concerns the gene PDGFRB and hyperinsulinemic hypoglycemia, familial, 4.