MAPT and Alzheimer disease: In particular, in AD, the formation of Aβ plaques (Ow and Dunstan, 2014), which is directly associated with the expression of SASP- associated factors (Bhat et al., 2012), and of NFT, composed by hyperphosphorylated tau protein, increase with the acquisition of a senescent phenotype and at the same time both induce senescence (Zare-Shahabadi et al., 2015; Chung et al., 2018; Mendelsohn and Larrick, 2018).