TP53 and Alzheimer disease: Increased senescence is found in different cell types of AD brains, including astrocytes, microglia, and neurons as demonstrated by their enhanced SA-β-gal expression (He et al., 2013), p53 expression, a mediator of cellular senescence (Arendt et al., 1996; McShea et al., 1997; Luth et al., 2000; Yates et al., 2015), an increase in the release of SASP components (Erusalimsky, 2009), DNA damage (Myung et al., 2008), telomere attrition or damage (Flanary and Streit, 2004), and senescence-like morphological changes (Streit et al., 2004).