Finally, tiagabine monotherapy appears to improve the performance of epilepsy patients on a number of neuropsychological tests (Dodrill et al., 1998), an effect that seems to relate to the report that heterozygous mice show greater learning and memory compared to wild-type and homozygous GAT-1−/− mice (Shi et al., 2012). This evidence concerns the gene SLC6A1 and epilepsy.