Similar to the brain of patients with schizophrenia, that of HRM exhibits a marked reduction in reelin, glutamic acid decarboxylase 67, dendritic spines, and synaptic function in the cortex and hippocampus (Tueting et al., 1999, 2006; Costa et al., 2001; Liu et al., 2001; Nullmeier et al., 2011), and abnormal behaviors, including impaired visual attention (Brigman et al., 2006), increased motor impulse (Ognibene et al., 2007), and persistent behavior (Macrì et al., 2010). This evidence concerns the gene RELN and schizophrenia.