Several researchers have found increased levels of artemin associated with tissue damage or inflammation in rodent pain models, such as CFA injection (Malin et al., 2006; Ikeda-Miyagawa et al., 2015; Lippoldt et al., 2016) and the nitroglycerin (NTG) migraine model (Shang et al., 2016). This evidence concerns the gene ARTN and migraine disorder.