SNCA and Parkinson disease: Finally, we observed the close correlation between the levels of the biochemical indicators such as FPG, cholesterol (CHOL), high density lipoprotein (HDL), low density lipoprotein (LDL) and TG and α-synuclein level and phosphorylation, indicating that T2DM is a risk factor of PD, particularly inducing prodromal pathological alterations in PD and related diseases.