Mutations in Vps13C, encoding a lipid-transfer protein localized at both ER-endosome and ER-LD MCSs (Kumar N. et al., 2018), are associated with PD, and cause mitochondrial dysfunction and PINK1/Parkin-dependent mitophagy (Lesage et al., 2016; Schormair et al., 2018). The gene discussed is PINK1; the disease is Parkinson disease.