Also, both AD patients and mouse AD models show decreased MFN2 protein levels, correlating with disruption of mitochondria dynamics (Wang et al., 2009; Manczak et al., 2011), and increasing ER-mitochondria MCSs ameliorates AD defects in a Drosophila model (Garrido-Maraver et al., 2019). Here, MFN2 is linked to Alzheimer disease.