Mutations in Vps13D, required for mitochondrial size and clearance (Anding et al., 2018), are also causative for recessive spastic paraplegia or ataxia (Gauthier et al., 2018; Seong et al., 2018), thus suggesting that lipid transfer to or from the ER might be vulnerable in HSP, although the exact subcellular compartments where Vps13D acts are still unknown. This evidence concerns the gene VPS13D and cerebellar ataxia.