VPS13D and hereditary spastic paraplegia: Mutations in Vps13D, required for mitochondrial size and clearance (Anding et al., 2018), are also causative for recessive spastic paraplegia or ataxia (Gauthier et al., 2018; Seong et al., 2018), thus suggesting that lipid transfer to or from the ER might be vulnerable in HSP, although the exact subcellular compartments where Vps13D acts are still unknown.