While the use of C5aR antagonist inhibits NPC proliferation in the ventricular zone of mouse embryos and lead to brain microstructural alterations and behavioral deficits (such as heightened anxiety, impaired coordination, and short-term memory) later in life (Coulthard et al., 2017), C5aR knockout mice exhibit increased proliferation of NPC within the ventricular zone (Coulthard et al., 2018a; Table 1). The gene discussed is NPC1; the disease is Anxiety.