Finally, the role of metabolic species regulating the NLRP3-inflammasome and neurodegeneration was recently evidenced by showing that the 25-hydroxycholesterol also activates the NLRP3-inflammasome pathway, promoting progressive neurodegeneration in X-linked adrenoleukodystrophy, a nervous disease with cerebral inflammatory demyelination (Jang et al., 2016). Here, NLRP3 is linked to X-linked adrenoleukodystrophy.