NFKB1 and Mental deterioration: For instance, microglia IKKβ/NF-κB ablation in the hypothalamus reverts cognitive decline in rodents (Zhang et al., 2013), whereas IKKβ/NF-κB activation under long-time exposure to a hypercaloric diet depletes and impairs neuronal differentiation of adult hypothalamic neural stem cells (Li et al., 2012).