EPHA2 and metastatic neoplasm: Our results from histological analysis of GPRC5A in primary and metastatic tumor specimens of advanced HGSC cohort, coupled to data from publicly available mRNA expression datasets, revealed the potential of this receptor as a biomarker for HGSC abysmal outcome and poor chemotherapy response, and also for aiding at the stratification of the unresponsive patients for treatment sensitization through novel combinatorial therapies, such as the RSK1/2‐EphA2‐pS897 pathway inhibition.