Moreover, immune‐related GS may provide prognostic and predictive information in BC, including early and metastatic ER+ BC (Denkert et al., 2015; Foukakis et al., 2018; Matikas et al., 2018), a tumor type traditionally considered as nonimmunogenic (Alexandrov et al., 2013). This evidence concerns the gene ESR1 and breast cancer.