For example, previous studies have suggested that polymorphisms in CASP8 are associated with breast cancer risk (Cox et al., 2007), whereas a recent paper has shown that the most significant signal in this region is for the imputed intronic SNP rs1830298 in ALS2CR12 (telomeric to CASP8; Lin et al., 2015). The gene discussed is CASP8; the disease is breast cancer.