Specifically, three of the previously reported genes were excluded by our stringent QC procedure (DHODH, ANKLE1 from Hoffman et al. and TP53INP2 from Gao et al. were not heritable in our analysis) and one was not significant in our analysis (RCCD1 from Hoffman et al. p = .0032 for overall breast cancer). This evidence concerns the gene ANKLE1 and breast carcinoma.