TNFSF10 and cancer: More recently, the angular form of ONC201/TIC10 was rediscovered in a drug screen searching for TRAIL-inducing compounds and found to have anti-cancer properties.7 On the molecular level, ONC201/TIC10 was shown to inhibit the DRD2 receptor causing downregulation of AKT and ERK signalling resulting in FoxO3a-mediated enhanced transcription of TRAIL.