ZBTB7A function in glycolysis regulation has so far not been studied extensively in the hematopoietic system, but the observed upregulation of glycolytic genes upon ZBTB7A mutation in our patient cohort [1] may counteract the growth arrest caused by RUNX1–RUNX1T1 in AML t(8;21). Here, RUNX1T1 is linked to acute myeloid leukemia.