Another regulation of Smad2/3 proteins showed that profilin-2 interacts with HDAC1 to inhibit the binding of HDAC1 to the promoters of Smad2 and Smad3, leading to their activation and enhancing the TGF-β-induced EMT and angiogenesis in lung cancer cells [35]. This evidence concerns the gene SMAD2 and lung carcinoma.