TP53 and head and neck cancer: This is particularly relevant in cancers of the head and neck in which mutations of the TP53 gene are associated with the worst outcomes [3] and where TCGA has reported a TP53 mutation frequency of over 80% in the majority of patients who are diagnosed with HPV negative squamous cell carcinomas of the head and neck (SCCHN), making this the single most frequent genetic event in this disease by a large margin [4].