Studies by Myers and colleagues have shown a dependence on glucose as a primary energy source in head and neck cancer cells and comparing HN30 (TP53 wild-type) and HN31 (TP53 C176F) cells as well as using RNAi in these lines, they demonstrated that the extent of this dependence was influenced by wild-type p53 expression levels and that glucose dependence was greatest in cells that harboured a TP53 mutation [16]. The gene discussed is TP53; the disease is head and neck cancer.