Furthermore, MetS is regarded as a state of chronic low grade inflammation which can result in increased levels of proinflammatory mediators like Tumor Necrosis Factor alpha (TNFα), Interleukin-1 (IL-1), Interleukin-6 (IL-6) Plasminogen Activator Inhibitor-1 (PAI-1), and C-Reactive Protein (CRP).9 This evidence concerns the gene SERPINE1 and metabolic syndrome.