Expressed in astrocytes and microglial cells in addition to neurons, α7-nAChRs are closely associated with anti-neuroinflammation through the cholinergic nervous system and may be a promising target molecule for the treatment Alzheimer’s disease, schizophrenia, Parkinson disease, and chronic pain [1, 14, 27, 38, 62, 66, 83]. This evidence concerns the gene CHRNA7 and Parkinson disease.