IL1B and varicocele: It is believed that hypoxia signalingpathway is responsible for pathogenesis of varicocele (7).However, there are studies suggesting that varicocelestimulates pro-inflammatory and inflammatory cytokinesrelease, such as interleukin-1 (IL-1), IL-6, IL-8 and tumornecrosis factor-alpha (TNF-α) (8-11).