However, the pathogenesisof PCOS is complex and not completely understood.Previous studies have shown that androgens and insulinplay key roles in the development of this disease (3, 4).PCOS patients have higher serum levels of testosteroneand insulin, triglycerides, cholesterol, and lower serumlevels of sex hormone-binding globulin (SHBG) and follicle stimulating hormones (FSH) compared tohealthy women (4, 5). This evidence concerns the gene SHBG and polycystic ovary syndrome.