Stereotactically implanted brain cancer cells expressing a bioluminescent reporter (U87-GL-GFP PDE7B H217Q cells) allowed for facile longitudinal localization and monitoring of tumor burden using a commercialBLI system,25,26 and FMT was used to quantify the delivery of ICG and LS301 to tumors (Fig. 1). Here, PDE7B is linked to brain cancer.