NFE2L2 and cancer: The aberrant activation of NRF2 is found in various cancers including the lung, gallbladder, esophagus, breast, head and neck, and renal cancers (Shibata et al. 2008; Wang et al. 2010; Shibata et al. 2011; Inoue et al. 2012; Onodera et al. 2014; Kanamori et al. 2015; Martinez et al. 2015; Cancer Genome Atlas Research Network 2016).