Mitsuishi et al. examined NRF2-dependent transcriptome and NRF2 cistrome (genome-wide NRF2 binding sites) using one of the KEAP1-mutant non-small cell lung cancer (NSCLC) cell lines, A549 cells, and found that several metabolic genes, those involved in the pentose phosphate pathway and NADPH production as well as glutathione synthesis, are directly regulated by NRF2. Here, NFE2L2 is linked to non-small cell lung carcinoma.