One suggestion would be to describe focal intense prostate lesions with visually higher uptake than the liver (similar or greater than parotid activity: miPSMA score 3) as PSMA expression has been proven to be higher in more aggressive PC as defined by Gleason score, with clinically significant cancer defined as Gleason score ≥ 4 + 3 [21, 25, 26]. The gene discussed is FOLH1; the disease is pachyonychia congenita.