This might be related to the absence of detailed and validated standardized criteria for the definition of a positive prostatic primary lesion based on [68Ga]Ga-PSMA-11 PET/CT: PROMISE criteria focus more on the extent and organ confinement of the primary prostate lesion and do not specifically define a prostatic primary lesion; PSMA-RADS is not applicable on the primary prostate cancer, and Fanti et al. criteria were developed to detect prostate cancer recurrent lesions [5–7]. This evidence concerns the gene FOLH1 and prostate carcinoma.