Insulin-like growth factor binding protein 7 (IGFBP-7, Fig. 4G) and tissue inhibitor of metalloproteinases 2 (TIMP-2, Fig. 4E), which are secreted soluble proteins as part of the uEV proteome, are of great interest as biomarkers to predict the risk of developing acute kidney injury (AKI). Here, TIMP2 is linked to acute kidney injury.