In this study, we investigated the effect of amylin and its alanog, pramlintide, on Aβ pathology, and identified a novel aspect of amylin and pramlintide in increasing the amyloidogenic processing of APP in TgSwDI mouse, a model for cerebral amyloid angiopathy (CAA) and AD, where both peptides increased γ-secretase complex level and APP localization in lipid rafts. The gene discussed is APP; the disease is Alzheimer disease.