To take advantage of the high replication ability of KST0650, an endothelium reticulum stress (ERS)-related gene encoding spliced activating transcription factor 6 (sATF6), which shows low expression in colon cancer tissues compared to the corresponding tumor-adjacent tissues and triggers cell apoptosis by inducing downstream molecules like Bax, Bak, and CHOP, was introduced into KST065032–37. The gene discussed is BAK1; the disease is malignant colon neoplasm.