ANG and amyotrophic lateral sclerosis: To determine whether stability, ribosomal activity, and aggregation propensity of ALS-associated ANG variants were related (i.e. dependent, as might occur if loss of stability resulted in a commiserate loss of activity), their relationships were tested using Spearman’s Rho and Kendall’s Tau, which demonstrated a lack of statistical correlation between these parameters (Fig. 1).