The most prevalent mutations associated with ALS include the genes SOD1 (superoxide dismutase 1), TARDP (TAR DNA-binding protein 43), C9orf72 (chromosome 9 open reading frame 72), ANG, FUS (RNA-binding protein FUS), Optineurin, and UBQLN2 (ubiquilin 2). Here, UBQLN2 is linked to amyotrophic lateral sclerosis.