Adjusting the risk of CVD for MBL levels, potential and traditional CV risk factors, revealed a significant association of CVD with male sex (p = 0.05), age (p < 0.001), disease duration (p < 0.001), APL+ (p < 0.001), hypertension (p < 0.001), hypercholesterolemia (p < 0.001) and history of smoking (p = 0.02) in the univariate analysis, while the association with MBL levels p = 0.34), disease activity (SLEDAI p = 0.9, PGA p = 0.56), BMI (p = 0.58) and DM (p = 0.12) did not reach statistical significance. The gene discussed is MBL2; the disease is familial hypercholesterolemia.