TNF and neoplasm: As shown in Supplementary Fig. 3, in vitro treatment with AnxA5 promotes the secretion of pro-inflammatory cytokines TNF-α and IL-12 and suppresses the production of anti-inflammatory, immunosuppressive cytokine TGF-β by bone-marrow-derived dendritic cells (BMDCs) and bone-marrow-derived macrophages (BMDMs) co-cultured with cisplatin-treated apoptotic TC-1 tumor cells.