To test our hypothesis, we fused the DNA sequence of murine H2-Db restricted epitope of HPV16-E7 (aa49-57: RAHYNIVTF) to that of AnxA5 to generate AnxA5-E7 fusion protein (Supplementary Fig. 8) and assessed the therapeutic efficacy of systemic AnxA5-E7 administration as compared to systemic administration of AnxA5 only or E7aa49-57 peptide only in TC-1 tumor-bearing mice treated with or without cisplatin (Fig. 5a). Here, ANXA5 is linked to neoplasm.