To do so, we treated TC-1 tumor-bearing mice with cisplatin and/or AnxA5-E7 with or without additional treatment with anti-PD-1, anti-PD-L1, or anti-TIM-3, using a delayed treatment schedule starting at 15 days after tumor challenge, when the tumors have reached the size of about 300 mm3 (Fig. 7a). The gene discussed is ANXA5; the disease is neoplasm.