Since chemotherapy has been shown to enhance the externalization of PS by stressed and apoptotic-tumor cells14 and the interaction between PS+ tumor cells with phagocytic innate immune cells help promote the immunosuppressive state of TME (reviewed in ref. 5), we hypothesize that AnxA5, by binding to PS, can prevent the induction of immune suppression by PS+ tumor cells. The gene discussed is ANXA5; the disease is neoplasm.