To investigate the role of lncRNA LDLRAD4-AS1 in CRC, we first examined the lncRNA LDLRAD4-AS1 expression levels in CRC cell lines, revealing that lncRNA LDLRAD4-AS1 expression was upregulated in all CRC cell lines compared with a normal cell line (NCM460) (p < 0.001, Fig. 1a). Here, LDLRAD4 is linked to colorectal carcinoma.