To confirm the ability of the rBH3 motif to mediate direct protein-protein interaction between MCL1 and P18 and elucidate the impact that this binding has on cell growth and viability we chose the neuroblastoma cell line, WAC2, which contains a homozygous deletion of P16, as the main cell model for these studies25. The gene discussed is MCL1; the disease is neuroblastoma.