As shown, overexpression of METTL14 resulted in remarkable decrease in XIST expression level (Fig. 5b), cell growth (Fig. 5c, d) and invasion (Fig. 5e and Additional file 9: Figure S7B) of CRC cells, which were consistent with the above results and confirmed the suppressive effects of METTL14 on CRC. The gene discussed is METTL14; the disease is colorectal carcinoma.