APOE and dementia: Positive ever-smoking status (p < 0.001), greater smoking pack years (p = 0.016), increased DNAm GrimAge age acceleration (AgeAccelGrim) (p < 0.001) and increased extrinsic epigenetic accelerated ageing (EEAA) (p = 0.047) reduced the risk for dementia, while positive APOE ɛ4 (p < 0.001) carrier status increased the risk for dementia.