BM responder T cells were not able to proliferate so firmly as Tresps from peripheral blood even after additional stimulation by anti-CD3/CD28 antibodies (42724.2 ± 10993.7 vs. 6093.3 ± 4547.6; p = 0.002; healthy blood vs. RA BM). The gene discussed is CD28; the disease is rheumatoid arthritis.