Moreover, in a small case-control study of 26 LC patients, tumor cells from HIV-positive subjects (n = 13) express much more the receptor B7-H3 expression compared to HIV-negative ones (n = 13), while tumor PD-L1 expression, as well as PD-1 and PD-L1 expression on tumor infiltrating lymphocytes (TILs) was similar between the two groups [74]. This evidence concerns the gene CD274 and laryngotracheoesophageal cleft.