Based on this study, NOS1 aroused the scientific interest of Fallin et al. They screened 440 SNVs of 64 genes for their associations with a risk of schizophrenia and bipolar affective disorder (BAD) (see Section 2.1.2 on “Depression and Bipolar Affective Disorder” regardingNOS1) in 597 (including 323 schizophrenic and 274 BAD) patients and their family members. This evidence concerns the gene NOS1 and major depressive disorder.