De OS Mansur et al. tested two potentially functional clinically relevant SNVs, namely G2087A (rs2297518) and C(−1026)A (rs2779249), of NOS2 in 148 women with migraines with auras and 52 women with migraine without auras in comparison with the control group consisting of 152 healthy women from Brazil. Here, NOS2 is linked to migraine disorder.