Gonçalves et al. investigated NOS3 SNVs T(−786)C (rs2070744), Glu298Asp (rs1799983), 27 bpvariable number of tandem repeats (VNTR), rs3918226, and rs743506 in 178 women with migraines, including 44 patients with auras and 134 patients without auras. This evidence concerns the gene NOS3 and migraine disorder.