With the increase in interest in AQP4 as a potential therapeutic target [1,5,16,19], and the implications AQP4 activity has on many neurological disorders [7,14,16,17,18,21,22,23,25,30,31,32,33,34,42,43], it is important to have a clear understanding of the myriad of ways in which AQP4 is known to be regulated. The gene discussed is AQP4; the disease is nervous system disorder.