Cellular and tissue-like 3-D-models of inherited eye diseases in general, and IRDs in particular, in combination with genome-editing technologies such as CRISPR-Cas9, will further advance our understanding of the function of homeobox genes, their place in the regulatory hierarchy of underlying retinal pathogenesis, and how their pathogenic alleles result in retinal disorders in order to create therapies for IRDs. The gene discussed is LBX1; the disease is eye disorder.