In our previous studies, we reported that mutant p53 proteins (p53-R175H, p53-R248H, and p53-R273H) were able to repress the transcription of SESN1 and SESN2, and consequently the amount of the SESN/AMPK complex, resulting in the inhibition of AMPK signaling in pancreatic and breast cancer cells [8,89]. The gene discussed is SESN1; the disease is breast cancer.