AKT1 and cancer: Aberrant dysregulation of phosphoinositide 3-kinase and Akt (PI3K/Akt) pathway plays a key role in many hallmarks of cancer and contributes to increase ROS levels through direct modulation of mitochondrial bioenergetics and activation of NOX, or through the generation of highly reactive metabolic by-products, as superoxide ions and H2O2 [105,106,107].