Interestingly, the low expression levels of SESN1, as well as of other autophagy and ROS-related genes, strongly correlated with reduced relapse free survival (RFS) and distant metastasis free survival (DMFS) of breast cancer patients carrying TP53 gene mutations conferring a prognostic value to mutant p53 and SESN1 expression [89]. This evidence concerns the gene TP53 and breast cancer.