The major players recruited in tumor microenvironment during inflammation are represented by inflammatory cells and by several biochemical mediators belonging to the wide family of cytokines, such as chemokines (CC, CXC, XC, and CX3C), tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), interleukin 6 (IL-6), TGF-β, and interleukin 10 (IL-10), which drive tumor aggressiveness by stimulating cell proliferation and motility [139,140]. Here, CXCR1 is linked to neoplasm.