In this sense, Agarwal et al. reported that the ectopic expression of three hot-spot mutant p53 proteins, as R175H, R248W, and R273H, led the hyper-phosphorylation of the mTORC1 targets S6K1 and 4EBP1 in both p53-null HCT116 colon carcinoma cells and H1299 non-small cell lung carcinoma, contrarily to wild type p53 that reduced mTORC1 activity, as revealed by the decreased phosphorylation of S6K1 and 4EBP1 [104]. The gene discussed is TP53; the disease is non-small cell lung carcinoma.