While localization of mutated BEST1 to the basolateral plasma membrane was established in our study in two independent patient cell lines well in agreement with results from overexpression studies in a MDCKII cell model [18], ADVIRC-associated mutation (c.704T>C; p.(V235A)) was previously reported to be mislocalized at least in part to the apical surface of hiPSC-RPEs from an ADVIRC patient [35]. The gene discussed is BEST1; the disease is autosomal dominant vitreoretinochoroidopathy.