Due to the lack of research studies concerning the association of genetic variants with Jordanian MS patient’s clinical data, a total number of 21 SNPs were studied within three genes (rs6897932, rs13188960, rs1494554, rs987107, rs987106, rs3194051, rs1494571, rs11567705, rs6871748, rs969128, and rs1494555 within IL7R; rs2365095, rs1922452, rs951818, rs870849, rs188255, and rs11227 within LAG3; and rs6074022, rs1883832, and rs11086996 within CD40) in 218 MS patients of the Jordanian Arab population. This evidence concerns the gene CD40 and myeloid sarcoma.