As the deregulation of the tubulin isotype, Tubb4b was also found in the brain of MPS I mice [49]; the deregulation of tubulin isoforms Tubb1, Tubb2a, Tubb3, Tubb4a, Tubb5, and Tubb6 found in the MPS IIIB mouse brain strongly suggests that microtubule dysfunction may underlie the pathogenic mechanisms of neurological disorders in specific MPS subtypes. The gene discussed is TUBB4A; the disease is mucopolysaccharidosis.