CC chemokines, such as thymus- and activation-regulated chemokine/CC chemokine ligand 17 (TARC/CCL17), macrophage-derived chemokine/CC chemokine ligand 22 (MDC/CCL22), regulated on activation normal T expressed, and secreted/CC chemokine ligand 15 (RANTES/CCL5), and interleukins (ILs), are key mediators in the inflammatory response in skin diseases such as AD, subsequently upregulating the B-cell synthesis of immunoglobulin E (IgE) [2]. Here, IGHE is linked to Alzheimer disease.