Consequently, mRNAs encoding VEGF-A, -C, -D, FGF-2, HIF1A or DLL4 that are expressed by tumour cells or microenvironment (such as DLL4 expressed by TIP cells which are furthest away from the circulating blood are still efficiently translated while cap-dependent initiation is compromised (Figure 3). The gene discussed is DLL4; the disease is neoplasm.