Indeed, alterations of rRNA 2′-O-ribose methylation directly affect translation of some mRNAs, which contain particular cis-regulator elements in their 5′ UTR (i.e., Internal Ribosome Entry Sites or IRES), such as the Insulin-like Growth Factor 1 Receptor (IGF1R) or Myc proto-oncogene (MYC), in breast cancer and leukemia [80,81,82]. The gene discussed is IGF1R; the disease is leukemia.