Downregulation of SNORA80E in H1944- and Calu-1-derived CD133+ cells reduces by 50% the expression of cancer stem cell-associated genes, namely POU domain class 5 transcription factor 1 (POU5F1 or Oct4), nanog homeobox (Nanog), SRY-box transcription factor 2 (Sox2), neurogenic locus notch homolog 1 (otch1), smoothened frizzled class receptor (Smo) and ATP binding cassette subfamily G member 2 (ABCG2). Here, SMO is linked to cancer.