Genomic sequencing of CML patients has identified additional genetic changes, like mutations of the tumor suppressor genes RB1, TP53, and CDKN2A [28], and highlighted the fact that BCR-ABL kinase mutations are only identified in approximately 50% of patients with poor responses and disease progression [29]. This evidence concerns the gene TP53 and chronic myelogenous leukemia, BCR-ABL1 positive.