FLT3 and acute myeloid leukemia: Combination of FTY720 or OP449 along with Idarubicin and Ara-C, drugs used in standard induction therapy in AML, or FLT3 inhibitors, as well as with tyrosine kinase inhibitors in CML, have a synergic effect and significantly reduced growth of leukemic cells [92,108,138,141].