PTPA and chronic myelogenous leukemia, BCR-ABL1 positive: Notably, small molecules that prevent SET-PP2A interaction such as FTY720, OP449, and CM-1231 re-activates PP2A, inhibiting cell proliferation and promoting apoptosis in AML and CML cell lines and primary patient samples [62,63,68,83,92,106,108,138,139,140].