IDH1 and cancer: Therefore, the overexpression of the wild-type IDH1 is often associated with the uncontrolled growth and survival of numerous cancers, including non-small cell lung carcinoma [9], primary glioblastomas (GBMs) [10], pancreatic ductal adenocarcinoma [11] and several hematological malignancies such as lymphomas or leukemias [12,13].