The cancer grade-dependent increase of PC/GPC in this study was also consistent with a quantitative 1D and 2D 1H HR-MAS total correlation spectroscopy study of 49 prostate surgical samples that demonstrated that high-grade (Gleason score ≥ 4 + 3) PCa had significantly higher proliferation (Ki67 labeling) and concentrations of PC and GPC than low-grade cancers [52]. Here, MKI67 is linked to cancer.