Indeed, CXCR4 expression is an independent prognostic marker for several malignancies including: AML, multiple myeloma, squamous cell carcinoma, gastric cancer, renal cancer, hepatocellular carcinoma, and colorectal cancer (CRC) [31,32,33,34,35,36,37]. The gene discussed is CXCR4; the disease is colorectal carcinoma.