Germinal center reaction is arbitrated by the action of Tfh cells through direct costimulatory signals and cytokine secretion [40], but it also requires additional regulation by Tfr cells to avoid the unwanted autoantibody production and autoimmune disease development, which is accomplished by follicular B cells suppression and Tfh cell cycle inhibition to block their antibody production [41]. Here, TFRC is linked to autoimmune disease.